The levels of serum interferon gamma-induced protein 10 in patients with acute pathogen infection
10.3969/j.issn.1673-4130.2018.09.018
- VernacularTitle:血清γ干扰素诱导蛋白10与C反应蛋白对儿童急性感染的诊断价值
- Author:
Cunyan LI
1
;
Xiao ZHANG
;
Jianguo LU
;
Youde CAO
;
Liming TAN
;
Xingping MA
Author Information
1. 湖南省人民医院/湖南师范大学附属第一医院检验科
- Keywords:
interferon gamma-induced protein 10;
acute viral infection;
acute bacterial infection;
C reactive protein;
receiver operating characteristic curve
- From:
International Journal of Laboratory Medicine
2018;39(9):1083-1086
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the levels of interferon gamma-induced protein 10(IP-10)in children with acute viral and bacterial infection.Methods There were three groups:acute viral infection group(51 ca-ses),acute bacterial infection group(52 cases),and healthy control group(51 cases).Serum IP-10 levels were detected by enzyme linked immunosorbent assay(ELISA),and serum C reactive protein(CRP)were deter-mined with BNⅡ automatic protein analyzer.Results The level of serum IP-10 and CRP were significantly different in different groups(P<0.05).Compared with control group,the level of IP-10 and CRP were higher in acute viral infection group or in acute bacterial infection group(P<0.05).The level of IP-10 was higher in acute viral infection group than that in acute bacterial infection group(P>0.05).The level of CRP was higher in bacterial infection group than that in acute viral infection group(P<0.05).The IP-10 levels in viral Infec-tion patients were not correlated with the CRP levels.The area under curve(AUC),sensitivity and specificity of IP-10 and CRP were 0.688 and 0.873,35.0% and 79.6%,96.1% and 98.0%.When cut-off value of predic-tive probability was 0.713,sensitivity and specificity were increased to 82.5% and 100.0%.Conclusion Ser-um IP-10,CRP and predictive probability are valuable in the diagnosis of acute pathogen infection in children.
