Efficacy of atomized budesonide treating neonatal bronchopulmonary dysplasia after discharge from hospital
10.3760/cma.j.issn.1673-4408.2018.06.011
- VernacularTitle:新生儿支气管肺发育不良出院后雾化布地奈德疗效观察
- Author:
Lili YI
1
;
Xiaohua HAN
;
Liyun LIU
;
Jia WANG
;
Huisheng YAO
;
Lina HAN
Author Information
1. 中国医科大学附属盛京医院小儿呼吸科
- Keywords:
Preterm infant;
Bronchopulmonary dysplasia;
Budesonide;
Efficacy
- From:
International Journal of Pediatrics
2018;45(6):456-459
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of atomized budesonide on neonatal bronchopulmonary dysplasia after discharge from hospital to 6 months of gestational age correction.Methods Analyse clinical data of fifty children with BPD,observe the effects of atomized budesonide (0.5mg inhaled q12h,at least 4weeks,course(15.4 ±6.16) weeks.When wheezing or dyspnea occurred:1mg of budesonide and 1.25ml of albuterol and ipratropium bromide inhaled q12h,2 ～ 4weeks.When respiratory frequency,heart rate and blood oxygen saturation reached normal,three concave improved obviously,lung rale disappeared,gradually reduce to no treatment)improving the clinical symptoms of children with BPD in 6 months after discharge,and observe the effects of atomized budesonide on reducing respiratory tract infection (including upper respiratory tract infection,pneumonia,wheezing and hospitalization).Results Through budesonide aerosol therapy,respiratory frequency and heart rate of children with BPD could be reduced,blood oxygen saturation could be elevated,and three concave could be improved at corrected gestational age of 3 months and 6 months.(P ＜ 0.05),and at 3 months of corrected gestational age,the mean therapy time in treatment group is(56.8 ±26.9) d,this shows that 4weeks'treatment of budesonide aerosol could improve clinical symptoms;Also with budesonide aerosol therapy,the time of oxygen inhalation after hospital could be shortened (P ＜0.05);but respiratory infection of children with BPD in 6 months after discharge could not reduced (P ＞ 0.05).Conclusion The treatment of budesonide atomization can improve the clinical symptoms of children with BPD after discharge from hospital to 6 months of gestational age correction,improve oxygen and shorten the time of oxygen inhalation after hospital,cannot reduce the incidence of respiratory infection.
