The association between Gal-3 and the effect of perindopril on ventricular remodelin
10.3969/j.issn.1671-8348.2018.03.018
- VernacularTitle:培哚普利改善心室重构作用与Gal-3的相关性
- Author:
Yuehua ZHANG
1
;
Shuren LI
;
Wenhao DENG
;
Lingling YANG
;
Xiao HAO
;
Sha LI
Author Information
1. 河北医科大学研究生学院/河北省人民医院心内一科
- Keywords:
galectin 3;
heart failure;
myocardial infarction;
ventricular remodeling;
perindopril
- From:
Chongqing Medicine
2018;47(3):346-348,352
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between Gal-3 and the effect of perindopril on ventricular remodeling in ischemic heart failure rabbit.Methods A rabbit model of ischemic heart failure was made by ligationof the anterior descending branch of the coronary artery.Thirty rabbits were divided into sham operation group,heart failure group and perindopril group.Determination of cardiac function by echocardiography after 4 weeks of treatment respectively;mRNA expression and protein content of Gal-3 were detected by Real-time PCR or Western-blob.Serum Gal-3 level was determinated by ELISA.Results Compared with sham operation group,mRNA expression and protein content of Gal-3,type Ⅰ collagen and type Ⅲ collagen increased and the serum level of Gal-3 increased in heart failure group(P＜0.05);compared with heart failure group,mRNA expression and protein content of Gal-3,type Ⅰ collagen and type Ⅲ collagen decreased and the serum level of Gal-3 was reduced in perindopril group(P＜ 0.05).Gal-3 was negativelycorrelated with heart function(r=-0.925,P＜0.05).Conclusion Effect of perindopril inhibiting myocardial fibrosis,slowing the ventricular remodeling and improving heart function associated with level of Gal-3.
