Predictors of Long-term Mortality after Hospitalization for Acute Exacerbation of COPD.
10.4046/trd.2006.60.2.205
- Author:
Hae Sun JUNG
1
;
Jin Hwa LEE
;
Eun Mi CHUN
;
Jin Wook MOON
;
Jung Hyun CHANG
Author Information
1. Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea. jinhwalee@ewha.ac.kr
- Publication Type:Original Article
- Keywords:
COPD;
Mortality determinants;
Heart rate;
Right ventricular systolic pressure
- MeSH:
Blood Pressure;
Bronchiectasis;
Cicatrix;
Cohort Studies;
Follow-Up Studies;
Heart Rate;
Hospitalization*;
Humans;
Mortality*;
Pulmonary Disease, Chronic Obstructive*;
Radiography;
Retrospective Studies;
Thorax;
Tuberculosis
- From:Tuberculosis and Respiratory Diseases
2006;60(2):205-214
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Acute exacerbations form a major component of the socioeconomic burden of COPD. As yet, little information is available about the long-term outcome of patients who have been hospitalized with acute exacerbations, although high mortality rates have been reported. The aim of this study was to determine predictors of long-term mortality after hospitalization for acute exacerbation of COPD. METHODS: We performed a retrospective cohort study of consecutive patients admitted to the hospital for COPD exacerbation between 2000 through 2004. Patients who had died in hospital or within 6-months after discharge, had tuberculosis scar, pleural thickening or bronchiectasis by chest radiography or had been diagnosed with malignancy during follow-up periods were excluded. RESULTS: Mean age of patients was 69.5 years, mean follow-up duration was 49 months, and mean FEV1 was 1.00L (46% of predicted). Mortality was 35% (17/48). In the multivariate Cox regression analysis, heart rate of 100/min or more (p=0.003; relative risk [RR], 11.99; 95% confidence interval [CI], 2.34-61.44) and right ventricular systolic pressure (RVSP) of 35mmHg or more (p=0.019; RR, 6.85; 95% CI, 1.38-34.02) were independent predictors of mortality. CONCLUSION: Heart rate and RVSP in stable state may be useful in predicting long-term mortality for COPD patients admitted to hospital with acute exacerbation.
