Suppression of Oxidative Stress of Modified Gongjin-Dan (WSY-1075) in Detrusor Underactivity Rat Model Bladder Outlet Induced by Obstruction.

Jin-Woo JUNG; Seung Hwan JEON; Woong Jin BAE; Su Jin KIM; Mun Su CHUNG; Byung Il YOON; Sae Woong CHOI; U Syn HA; Sung Yeoun HWANG; Sae Woong KIM

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Suppression of Oxidative Stress of Modified Gongjin-Dan (WSY-1075) in Detrusor Underactivity Rat Model Bladder Outlet Induced by Obstruction.

Author: Jin-Woo JUNG ¹ ; Seung Hwan JEON ² ; Woong Jin BAE ² ; Su Jin KIM ² ; Mun Su CHUNG ¹ ; Byung Il YOON ¹ ; Sae Woong CHOI ² ; U Syn HA ² ; Sung Yeoun HWANG ³ ; Sae Woong KIM ⁴
Author Information

1. Department of Urology, International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon, Republic of Korea.
2. Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
3. Korea Bio Medical Science Institute, Seoul, Republic of Korea.
4. Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. ksw1227@catholic.ac.kr.
Publication Type:Journal Article
Keywords: anti-oxidant; detrusor underactivity; herbal
From: Chinese journal of integrative medicine 2018;24(9):670-675
CountryChina
Language:English
Abstract:
OBJECTIVETo investigate the anti-oxidative stress and preventive effect of modified Gongjin-dan (WSY-1075) in a detrusor underactivity rat model.
METHODSRats were randomly allocated to three groups: shamoperated (control), bladder outlet obstruction-induced detrusor underactivity (BOO-DU), and BOO-DU with WSY-1075 (WSY) groups. WSY-1075 was orally administrated to rats 200 mg daily for 2 weeks prior to the operation and 4 weeks after the operation. Bladder outlet obstruction was surgically induced in rats by ligation around the urethra avoiding total obstruction. Cystometrography was conducted on rats in each group for examination of bladders.
RESULTSCompared with the control group, bladder outlet obstruction led to a significant increase in oxidative stress with consequent changes to molecular composition, and decrease in maximal detrusor pressure (P<0.05). WSY-1075 treatment significantly suppressed oxidative stress and prevented degenerative and dysfunctional changes in bladder, as compared with BOO-DU group (P<0.05).
CONCLUSIONWSY-1075 had beneficial effect on prevention of BOO-DU.