Reviews on natural naphthoquinones and their bioactivities.
10.19540/j.cnki.cjcmm.20180530.002
- Author:
Chang-Kang LI
1
;
Xian-Ming SU
1
;
Feng-Hua LI
1
;
Chen-Chen GUAN
2
;
Bao-Ming LI
1
;
Ruo-Yun CHEN
1
;
Jie KANG
1
Author Information
1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
2. Yiling Pharmaceutical Co.Ltd., Shijiazhuang 063000, China.
- Publication Type:Journal Article
- Keywords:
anti-inflammatory;
antibacterial;
antioxidative;
cytotoxicity;
naphthoquinones
- From:
China Journal of Chinese Materia Medica
2018;43(18):3644-3651
- CountryChina
- Language:Chinese
-
Abstract:
The naphthaquinones are widely distributed in plants. They are usually in higher plants, but a few of them were also found in microorganisms. There is a lot of research showing that they had multiple pharmaco-activities such as cytotoxic, antioxidant, anti-inflammatory and antibacterial activities, etc. In recent years, they have attracted extensive attention at home and abroad especially in terms of the anti-tumor activity. For further research, 69 new natural naphthoquinones reported in the last five years (2013-2017) were reviewed. They were divided into five major types: simple 1,4-naphthoquinones, furan and pyran naphthoquinones, 1,2-naphthoquinones, naphthohydroquinones and naphthoquinone polymers, which showed cytotoxic, antioxidative, anti-inflammatory and antibacterial biological activities, et al. The research of these compounds in the future was also proposed.
