Triterpenoids from Uygur medicine latex of Euphorbia resinifera.
10.19540/j.cnki.cjcmm.20180625.003
- Author:
Shu-Yun WANG
1
;
Guo-Yu LI
2
;
Ke ZHANG
2
;
Hang-Yu WANG
2
;
Hong-Gang LIANG
3
;
Chao HUANG
4
;
Jian HUANG
3
;
Jin-Hui WANG
2
;
Bao-Feng YANG
3
Author Information
1. School of Pharmacy, Henan University, Kaifeng 475004, China.
2. School of Pharmacy, Shihezi University (Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education), Shihezi 832001, China.
3. Department of Medicinal Chemistry and Natural Medicine Chemistry (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin 150081, China.
4. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
- Publication Type:Journal Article
- Keywords:
Euphorbia resinifera;
Uygur medicine;
chemical constituents;
cytotoxicity;
triterpenes
- From:
China Journal of Chinese Materia Medica
2018;43(18):3688-3693
- CountryChina
- Language:Chinese
-
Abstract:
Ten triterpenes compounds were isolated from the methanol extraction of the latex of Euphorbia resinifera by means of various chromatographic methods such as silica gel, ODS and semi-preparative HPLC, Their structures were identified by spectroscopic methods and physicochemical properties. These isolated compounds were identified as 3-hydroxy-25,26,27-trinor eupha-8-ene-24-oate (1), iso-maticadienediol (2), 25,26,27-trinorTirucall-8-ene-3-ol-4-acid (3), dammarendiol Ⅱ (4), eupha-8,24-diene-3-ol-26-al (5), lnonotusane C (6), eupha-8,24-diene-3-ol-7,11-dione (7), inoterpene A (8), inoterpene B (9), and eupha-24-methylene-8-ene-3-ol-7,11-dione (10). Among them, compound 1 was a new natural product, compounds 2-4 were firstly isolated from the Euphorbiaceae and compounds 5 and 6 were isolated from the genus Euphorbia for the first time. The cytotoxicity of the compounds 1-10 against MCF-7, U937 and C6 cancer cell lines was evaluated, but none of the compounds was active.
