The Safety and Immune-efficacy of Fucoidan from Gagome Kombu (Kjellmaniella crassifolia) on Women with the History of Gynecological Cancer

Hoko KYO; Shintaro HASHIMOTO; Koji KOIKE; Kazuo UEBABA; Hiromu OHNOGI; Nobutaka SUZUKI

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The Safety and Immune-efficacy of Fucoidan from Gagome Kombu (Kjellmaniella crassifolia) on Women with the History of Gynecological Cancer

VernacularTitle:The Safety and Immune-efficacy of Fucoidan from Gagome Kombu (Kjellmaniella crassifolia) on Women with the History of Gynecological Cancer
Author: Hoko KYO ¹ ; Shintaro HASHIMOTO ² ; Koji KOIKE ³ ; Kazuo UEBABA ⁴ ; Hiromu OHNOGI ¹ ; Nobutaka SUZUKI ⁵
Author Information

1. Urata Clinic, Hospy Medical Association
2. Department of Complementary and Alternative Medicine Clinical Research and Development, Kanazawa University Graduate School of Medical Science
3. Daimyomachi Skin Clinic
4. Koike Ladies Clinic
5. Faculty of Health Care, Teikyo Heisei University
Keywords: Fucoidan; Gagome Kombu; gynecological cancer; immune-efficacy; safety
From:Japanese Journal of Complementary and Alternative Medicine 2018;15(1):29-35
CountryJapan
Language:Japanese
Abstract: Objective: Fucoidan is a sulfated polysaccharide in brown seaweeds. Previous studies show that fucoidan from Gagome kombu (GKF) exhibit immune-enhancing capabilities on healthy adults. In this study, we focused on the women with the history of gynecological cancer and evaluated the safety and immune-efficacy of GKF.Methods: Ten Japanese women subjects were chosen to ingest the test samples (1 drink / day containing 200 mg GKF) for 4 weeks. Before and after ingestion, blood chemistry analysis, hematological analysis, urinalysis and immune analysis were conducted. Result: Results showed no adverse clinical changes in blood and urinary analysis. In addition, no serious symptoms were observed. Moreover, decrease of serum levels of Eotaxin, IL-7, IL-17 and VEGF were observed.Conclusion: These results indicate that in the case of women with the history of gynecological cancer, GKF is a safe functional food ingredient.