Medication regularity and potential targets of Professor XU Jing-fan's prescription for treating ulcerative colitis.
10.19540/j.cnki.cjcmm.2018.0035
- Author:
Li-Qin NING
1
;
Bai YE
1
;
Hong SHEN
1
;
Wei-Min LU
1
;
Dan-Hua XU
1
;
Jing YAN
2
;
Chang TAN
1
;
De-Cai TANG
2
Author Information
1. The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210009, China.
2. Nanjing University of Chinese Medicine, Nanjing 210023, China.
- Publication Type:Journal Article
- Keywords:
BATMAN-TCM;
medication regularity;
molecular target;
traditional Chinese medicine inheritance;
ulcerative colitis
- From:
China Journal of Chinese Materia Medica
2018;43(5):1042-1048
- CountryChina
- Language:Chinese
-
Abstract:
Ulcerative colitis (UC) is a chronic nonspecific inflammation mainly involving rectum and colon mucosa, which seriously affects the health and quality of life of patients, and is listed as one of modern refractory diseases by WHO. Professor XU Jing-fan, a great master of traditional Chinese medicine, has accumulated rich experiences in the treatment of UC. The study collected Professor XU's 77 prescriptions of treating UC, analyzed the frequency of traditional Chinese medicines and there categories, and investigated the medication regularity by the system clustering method. The findings showed that the most frequently used drugs were clearing-heat herbs, which were followed by hemostatic herbs, excreting-dampness herbs, improving-digestion herbs and tonifying-Qi herbs. At the same time, the commonly combined drugs were excavated. Finally, in order to analyze potential molecular targets of the frequently used herbs, GO enrichment analysis and KEGG signal pathway enrichment analysis were performed with bioinformatics analysis tool for molecular mechanism of traditional Chinese medicine (BATMAN-TCM). The results indicated that Chinese herbal compounds may treat UC by activating PPAR-γ pathway and regulating intestinal inflammation. The exact mechanisms shall be verified through subsequent molecular biological experiments.
