Effect of animal medicines for "extinguishing wind to arrest convulsions" on central nervous system diseases.
10.19540/j.cnki.cjcmm.20171113.015
- Author:
Zhi-Jie YU
1
;
Jin-Song LI
2
;
Wei PENG
1
;
Ping WANG
1
;
Liang XIONG
1
;
Yu-Jie LIU
1
;
Ying XU
1
;
Tao SUN
1
Author Information
1. Key Laboratory of Standardization for Chinese Herbal Medicine, Ministry of Education, National Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
2. The First People's Hospital of Guangyuan City, Guangyuan 628017, China.
- Publication Type:Journal Article
- Keywords:
active ingredient;
animal medicines;
central nervous system disease;
extinguishing wind to arrest convulsions;
pharmacological effect
- From:
China Journal of Chinese Materia Medica
2018;43(6):1086-1092
- CountryChina
- Language:Chinese
-
Abstract:
The human health is seriously affected by central nervous system(CNS) diseases, but the pathogenesis of CNS diseases is still not completely clear. Currently, the drugs used to treat CNS diseases are mainly receptor modulators and neurotransmitter inhibitors, which have serious side effects; and there are short of drugs for treating CNS diseases clinically. Studies suggest that animal medicines mainly include protein, polypeptide and small-molecule compounds, and have such pharmacological effects in calming, resisting convulsions and improving brain tissues. Plenty of studies suggest that animal medicines usually have a strong activity and good curative effect on these diseases, with a promising prospect in research and development of drugs treating CNS diseases. Based on systematic reviews of literatures, this paper summarizes active ingredients and main pharmacological effects of animal medicines in "extinguishing wind to arrest convulsions" for the CNS diseases, epilepsy and cerebral ischemia, and discusses their study value and application prospects. The results showed that the studies of protein and peptides were relatively simple, and some animal medicines were still blank. The authors believed that amino acids and small molecular compounds should be transferred to oligopeptide, advanced protein extraction and separation techniques shall be adopted for identifying the protein polypeptide composition structure and studying the efficacy, and the methods of biological technology were used to develop peptide biological products for the treatment of CNS diseases. This paper could provide ideas and reference for developing animal medicine products for the treatment of CNS diseases.
