Research progress of platelet activating factor(PAF) receptor antagonist.
10.19540/j.cnki.cjcmm.20180312.003
- Author:
Xue-Qing LI
1
;
Ting GENG
1
;
Wen-Zhe HUANG
1
;
Zhen-Zhong WANG
1
;
Wei XIAO
1
Author Information
1. Jiangsu Kanion Parmaceutical Co., Ltd., Lianyungang 222001, China.
- Publication Type:Journal Article
- Keywords:
active components;
biological effect;
lignans;
platelet activating factor;
terpenes
- From:
China Journal of Chinese Materia Medica
2018;43(7):1392-1403
- CountryChina
- Language:Chinese
-
Abstract:
Platelet activating factor(PAF), an endogenous synthesized phospholipid transmitter, has widely biological activities. It has "signal transmission" effect in various life processes, but abnormality of concentration will promote or aggravate the diseases, such as, cerebral ischemia, myocardial injury, multi-organ failure, asthma, injury of liver and kidney, severely affecting the normal life activities of body. In recent years, with the development of medical science and technology, more and more attention has been paid to the research of platelet activating factor receptor antagonist. Components of animals, plants, microbial fermentation, and synthetic composition all can reflect such activity. Ginkgolide B and cytopone are the most representative herbal compositions at present. This paper referred to the research status of platelet activating factor receptor antagonist in recent years, made a summary of the researches on biological effect of platelet activating factor and platelet receptor antagonist of different sources, so as to provide a reference for the exploration of effective and safe platelet activating factor receptor antagonists.
