Increased Serum Cystatin C in Early Parkinson's Disease with Objective Sleep Disturbances.

Kang-Ping XIONG; Yong-Ping DAI; Jing CHEN; Jin-Min XU; Yi WANG; Ping FENG; Shou-Jiang YOU; Chun-Feng LIU

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Increased Serum Cystatin C in Early Parkinson's Disease with Objective Sleep Disturbances.

Author: Kang-Ping XIONG ¹ ; Yong-Ping DAI ² ; Jing CHEN ¹ ; Jin-Min XU ¹ ; Yi WANG ¹ ; Ping FENG ³ ; Shou-Jiang YOU ¹ ; Chun-Feng LIU ⁴ ;
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1. Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China.
2. Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu 215123, China.
3. Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China.
4. Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004
Publication Type:Journal Article
Keywords: Cystatin C; Early Parkinson's Disease; Objective Sleep Disturbance
MeSH: Aged; Cystatin C; blood; Female; Glomerular Filtration Rate; physiology; Humans; Male; Middle Aged; Parkinson Disease; blood; physiopathology; Polysomnography; Sleep Wake Disorders; blood; physiopathology
From: Chinese Medical Journal 2018;131(8):907-911
CountryChina
Language:English
Abstract:
BackgroundSleep disturbance is one of the major non-motor symptoms which cause the disability of Parkinson's disease (PD) patients. Cystatin C (CysC) is a more sensitive biomarker than serum creatinine or estimated glomerular filtration rate. Previous studies have reported altered CysC levels in neurodegenerative disorders and sleep disorders. This study aimed to explore the correlations of serum CysC levels and objective sleep disturbances in early PD.
MethodsWe recruited 106 early PD patients and 146 age- and sex-matched controls. All participants underwent clinical investigation and video-polysomnography. Sleep parameters and serum levels of CysC were measured. Then, we investigated the relationships between CysC and clinical variables and objective sleep disturbances in early PD patients.
ResultsThe mean serum level of CysC was significantly higher in patients with early PD (1.03 ± 0.19 mg/L) compared to controls (0.96 ± 0.15 mg/L, P = 0.009). There were significantly positive correlations between serum CysC levels and age (r = 0.334, P < 0.001), gender (r = 0.264, P = 0.013), and creatinine levels (r = 0.302, P = 0.018) in early PD patients. Increased serum CysC levels in early PD patients were significantly associated with higher apnea and hypopnea index (AHI) (r = 0.231, P = 0.017), especially hypopnea index (r = 0.333, P < 0.001). In early PD patients, elevated serum CysC levels were positively correlated with oxygen desaturation index (r = 0.223, P = 0.021), percentage of time spent at oxygen saturation (SaO) <90% (r = 0.644, P < 0.001), arousal with respiratory event during sleep (r = 0.247, P = 0.013). On the contrary, the elevated serum CysC levels were negatively correlated with mean and minimal SaO(r = -0.323, -0.315, both P = 0.001) in PD patients.
ConclusionsThe level of serum CysC was higher in early PD patients. PD patients with elevated serum CysC levels had more respiratory events and more severe oxygen desaturation. Therefore, the serum CysC levels may predict the severities of sleep-disordered breathing problems in early PD patients.