The experimental study of 5-FU on inhibiting angiogenesis
- VernacularTitle:氟尿嘧啶抗血管生成作用的实验研究
- Author:
Ming YIN
;
Longbang CHEN
;
Huaicheng GENG
;
Jing ZANG
;
- Publication Type:Journal Article
- Keywords:
FU;
Angiogenesis;
HUVEC;
Chick chorioallantoic membrane
- From:
Journal of Medical Postgraduates
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the antiangiogenesis ability of 5 FU. Methods:Human umbilical vein endothelial cells were cultured primarily in vitro and influence of 5 FU on HUVEC proliferation was evaluated by MTT method. Chick chorilallantoic membranes(CAM) model was used to check whether the neovascularization of CAM could be suppressed in vivo . Results:5 FU both inhibited proliferation of HUVEC in vitro and suppressed angiogenesis of CAM in vivo at none cytotoxic doses. Conclusion: 5 FU demonstrated antiangiogenesis ability without obvious cytotoxicity.
