Preparation and cariostatic property of sodium fluoride gelatin microspheres
- VernacularTitle:氟化钠明胶微球的制备及其体外抑龋试验
- Author:
Hongping ZHAO
;
Buling WU
;
Hong WU
;
Daocheng WU
;
Jucai YANG
;
- Publication Type:Journal Article
- Keywords:
Fluoride;
Gelatin microspheres;
Cariostatic property;
Dental plaque;
Demineralization
- From:
Journal of Medical Postgraduates
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To study the preparation techniques of gelatin microspheres encapsulated with sodium fluoride and evaluate the anticaries functions in dental plaque model in vitro. Methods:Fluoride gelatin microspheres were prepared by emulsion polymerisation method. The encapsulation rate and drug contents were tested by ISE. In vitro inhibition of demineralization were also examined. Results:The mean size of fluoride GMS was (16.81?8.77)?m.The encapsulation rate was 76.73%.The drug content was 5.61%.The release profile in vitro showed sustained effects. Fluoride GMS can prevent demineralization more efficiently. Conclusions:Fluoride gelatin microspheres may be an promising topical fluoride release system.
