Effect of Breviscapine on L-type Calcium Channel in the Hippocampal CA1 Neurons of Whole Brain Ischemiareperfusion Rat Model
- VernacularTitle:灯盏花素对大鼠全脑缺血再灌注后海马神经元L型钙通道的影响
- Author:
Lequan ZHOU
;
Yali KANG
;
Shengyuan DING
;
Fuman YAN
;
Xiaoying LI
;
- Publication Type:Journal Article
- Keywords:
Breviscapine;
Cerebral ischemia-reperfusion;
L-type calcium channel
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of breviscapine on the open probability(Po)and the average open time(To) of L-type calcium channel in the hippocampal neurons of the whole brain ischemia-reperfusion rat model.Methods The whole brain ischemia rat model was established.At the reperfusion periods of 1.5 h,3.0 h,4.5 h and 6.0 h,the hippoeampal CA1 neurons were dissociated abruptly and the Ca~(2+)electricity of single channel on the neuron membrane were recorded with cell-attach model of patch clamp techniques.The Po and To of the L-type calcium channel were an- alyzed and the effect of the breviscapine was observed.Results Different concentrations of breviscapine can decrease the Po and To of the L-type calcium channel in hippoeampal neurons,particularly within 3 hours after ischemia-reperfu- sion.Conclusions Breviscapine has protective effect on the cerebral ischemia-reperfusion injury.
