Association between rheumatoid arthritis and shared epitope of HLA-DRB1 gene in Shandong population
- VernacularTitle:山东地区类风湿关节炎与HLA-DRB1基因共同表位的关联性研究
- Author:
Xingfu LI
;
Fang ZHANG
;
Zhenglun PAN
;
Yuyan MA
;
Huaxiang LIU
;
- Publication Type:Journal Article
- Keywords:
Arthritis,rheumatoid;
HLA DRB1 gene;
Shared epitope
- From:
Chinese Journal of Rheumatology
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between rheumatoid arthritis (RA) and the presence of the shared epitope (SE) of HLA DRB1 gene in Han nationality of Shandong population.Methods The method of DNA amplification with sequence specific primers (PCR SSP) was used to determine 17 alleles of HLA DRB101,04,10 genotypes in 132 RA patients and 130 healthy controls from the Han nationality population in Shandong.Results The frequencies of SE were significantly increased in RA patients compared with controls (50 0% vs 22 3%, P
