Abnormal Th cell differentiation associated gene expression in systemic lupus erythematosus patients

VernacularTitle:系统性红斑狼疮初发患者Th细胞异常分化相关分子基因表达研究
Author: Li LI ; Shunle CHEN ; Nan SHEN ; Chunde BAO ; Jie QIAN ; Ping YE ; Yueying GU ; Yuan WANG ;
Publication Type:Journal Article
Keywords: Lupus erythematosus,systemic; Gene expression regulation; Th1 cells; Th2 cells
From: Chinese Journal of Rheumatology 2002;0(03):-
CountryChina
Language:Chinese
Abstract: Objective To continue to study if there is any other pathogenic gene expression related to Th1/Th2 abnormal differentiation,based on the author′s previous results,which have shown that Th1/Th2 unbalance is due to the cytokines and cytokine receptors of differentiation.Methods TaqMan Real time PCR was used to detect the gene expression of Th1/Th2 control in recent onset systemic lupus erythematosus (SLE) patients ( n =38).The genes include I?B,IRF 1,STAT4,GATA3,IL 4R and the others such as CCR1,CCR2,CCR4,CCR5,caepase 1 and CD38,which participate in inflammation,cell apoptosis and so on.Rheumatoid arthritis (RA) patients ( n =50) and normal people ( n =28) were control groups.Results ① Resent onset SLE patients comparing to normal people:STAT4 expression in IL 2/IL 12R ? 2/STAT4 access which induced Th1 differentiation increased significantly ( P 0 05) ;GATA3 expression which induced Th2 differentiation in IL 4/IL 4R/GATA3 access decreased significantly ( P