Interstitium revascularization and related cytokine regulation in myocardium of rheumatic heart disease
- VernacularTitle:风湿性心脏病心肌间质血管改建及相关细胞因子的调节
- Author:
Jinbao ZHANG
;
Yiwei WANG
;
Weiyong LIU
;
Chonglei REN
;
- Publication Type:Journal Article
- Keywords:
Rheumatic heart disease;
Myocardium;
Growth substances;
Fibrosis
- From:
Chinese Journal of Rheumatology
2001;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the interstitial revascularization and related cytokine regulation in myocardium of rheumatic heart disease.Methods The specimens were stained by HE to examine the ratios between arteriolar inner and outer diameters and by immunohistochemical staining and in situ hybridization to measure the expression of bFGF,vascular endothelial growth factor (VEGF),? SMA and mRNA of bFGF.Then the relationship between ratios of arteriolar inner and outer diameters and expression of bFGF,VEGF and ? SMA.Results The imaging analysis indicated that there was significant myocardium fibrosis,and the arteriolar wall became thick (0 68?0 15 vs 0 40?0 04).The expression of bFGF,VEGF and ? SMA in the myocardium of rheumatic heart disease was significantly higher than that of healthy adult control group.There was a positive relationship between ratios of arteriolar inner and outer diameters and expression of bFGF,VEGF and ? SMA (bFGF r =0 719, P
