Radiofrequency hyperthermia in combination with continuous intra-arterial infusion chemotherapy in the treatment of advanced colorectal cancer
- VernacularTitle:射频透热联合动脉持续灌注化疗治疗晚期肠癌的临床疗效
- Author:
Yan ZHAO
;
Senming WANG
;
Jian ZHANG
;
Wen ZHOU
;
- Publication Type:Journal Article
- Keywords:
Advanced colorectal cancer;
Radiofrequency hyperthermia;
Chemotherapy
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2003;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the therapeutic efficacy of continuous arterial infusion chemotherapy combined with radiofrequency hyperthermia in the treatment of patients with advanced colorectal cancer. Methods A total of 21 advanced colorectal cancer patients with various distant metastasis were treated by the combined continuous intra arterial infusion chemotherapy and radiofrequency hyperthermia. For the chemotherapy, a dose of 200mg/m 2 surface body area of calcium folinate (CF) was given for 1 to 3 days. 80mg/m 2 of cisplation was infused intravenously for the first day and replaced by etoposide Vp 16, 60mg/m 2 for 1～3days in patients with renal dysfunction. For intra arterial infusion, a dose of 500mg/m 2 5 FU 2 was given for 72 hours. For patients with liver metastases, chemoembolization(ADM 30mg/m 2+MMC 6mg/m 2 mixed with ultra liquefied lipiodol) was carried out. Radiofrequency hyperthermia with a frequency of 41MHz was performed on the second day after chemotherapy. Results Response rates were assessed by CT scan and ultrasonography. The overall response rate of the cases was 66.67%. No serious side effect or complication was found in the course of chemotherapy. Local pain and lipid nodule were occasionally observed in some patients after hyperthermia. Conclusion Continuous intra arterial infusion chemotherapy in combination with radiofrequency hyperthermia is an useful and safe method for the treatment of patients with advanced colorectal cancer.
