Effects of Compound Danshen Injection on Local Angiotensin Ⅱ in Rat kidney with Unilateral Ureteral Obstruction
- VernacularTitle:复方丹参注射液对单侧输尿管结扎大鼠肾内局部血管紧张素Ⅱ的作用
- Author:
Qingyou XU
;
Yuyong ZHAO
;
Huazhou XU
;
Li ZHU
;
Gang CAO
;
Yanhong WEI
;
- Publication Type:Journal Article
- Keywords:
unilateral ureteral obstruction;
Compound Danshen Injection;
benazepril;
angiotensin Ⅱ;
angiotensin converting enzyme;
endothelin
- From:
Chinese Traditional Patent Medicine
1992;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the protective effects of Compound Danshen Injection and Benazepril on rats with obstructive nephrosis.Methods:The interstitial nephritis model of rat was established by ligating unilateral ureter. The model rats were given drug Compound Danshen Injection and Benazepril, respectively. The levels of angiotensin Ⅱ (Ang Ⅱ), endothelin (ET 1) and the activity of angiotensin converting enzyme (ACE) in renal tissues were measured. Results: The level of angiotensin Ⅱ of Compound Danshen Injection group was 42.03?13.95pg/mg lower that of pathologic group (80.19?27.31pg/mg). The level of Benazepril group was 32.53?8.07pg/mg. There were significant differences among them. The measuring results of ACE and ET 1 were similiar to that of Ang Ⅱ.Conclusion: Compound Danshen Injection and Benazepril can effectively inhibit the activity of ACE and decrease the levels of Ang Ⅱ and ET 1.
