Effect of azelastine hydrochloride on experimental asthma and its mechanism in guinea pigs
- VernacularTitle:盐酸氮斯汀对豚鼠实验性哮喘的作用及其机理研究
- Author:
Shiqin JIANG
;
Guangqing YU
;
- Publication Type:Journal Article
- Keywords:
azelastine hydrochloride;
asthma;
histamine;
chlorpheniramine maleate;
guinea pigs
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To probe the effect of azelastine hydrochloride on experimental asthma and its mechanism. METHODS: Experimental asthma models of guinea pigs induced by histamine and acetylcholine in vivo as well as guinea pig tracheal spirals in vitro were used in this experiment. RESULTS: Azelastine hydrochloride inhibited asthma induced by histamine and acetylcholine in guinea pigs in a dose dependent manner, prolonged the incubation period of histamine and acetylcholine induced asthma (P
