Application of clopidogrel in percutaneous coronary intervention for acute occlusions of coronary arteries
- VernacularTitle:氯吡格雷在急性冠状动脉闭塞介入治疗中的疗效与安全性评价
- Author:
Shan SUN
;
Shangqin WU
;
Jing XU
;
Dongmei CHEN
;
Huizhong WANG
;
- Publication Type:Journal Article
- Keywords:
clopidogrel;
ticlopidine;
acute occlusions of coronary arteries
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2002;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To observe the effects and safety of clopidogrel used in percutanous coronary intervention (PCI) while acute occlusions of coronary arteries happened. METHODS: 92 patients with acute occlusions of coronary arteries were treated through PCI and they were randomized equally into following groups: clopidogrel group (CPG group) and ticlopidine group (TCP group). Each patient was treated with clopidogrel 25 mg bid or ticlopidine 250 mg bid for 4 weeks after PCI. RESULTS: Compared with the control group, there was not significantly difference in platelet aggregation ( 45.36 ? 2.98 vs 51.60 ? 2.56 ) and clinical effects ( 97.95 % vs 93.02 %) after 3 weeks. The proportion of patients with adverse events who had to release the treatment was 2.04 % (CPG group) and 16.27 % (TCP group). CONCLUSION: The clinical effect of clopidogrel is similar to ticlopidine and shows less adverse events.
