Reverse effect of losartan on myocardial fibrosis and left ventricular hypertrophy in treatment of essential hypertensive patients
- VernacularTitle:氯沙坦逆转高血压患者心肌肥厚及心肌纤维化的作用
- Author:
Wenhui LIN
;
Yukang SONG
;
Xiangjun MA
;
- Publication Type:Journal Article
- Keywords:
losartan;
hypertension;
left ventricular hypertrophy;
myocardial fibrosis
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2002;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the effects of losartan on myocardial fibrosis and left ventricular hypertrophy in hypertensive patients. METHODS: 35 essential hypertensive patients with left ventricular hypertrophy were treated with losartan 50-100 mg for 6 mon. Before and after the treatment, serum procollagen typeⅢ (PCⅢ), laminin (LN), and hyaluronic acid (HA) were measured by radioimmunoassay; and left ventricular mass index (LVMI) was determined with ultrasonic cardiogram. RESULTS: After treatment with losartan: the serum levels of PCⅢ, LN, HA, and LVMI were all decreased (P
