Effect of pregnenolone sialic glycoside on memory impairment in mice
- VernacularTitle:孕烯醇酮唾液酸苷对小鼠记忆障碍的改善作用
- Author:
Bin ZHOU
;
Qin ZHANG
;
Zaorui ZHAO
;
Wenji LI
;
Shaoshun LI
;
Yuanying JIANG
;
Ming YIN
;
- Publication Type:Journal Article
- Keywords:
pregnenolone sialic glycoside;
pregnenolone sulfate;
scopolamine;
learning and memory;
water maze
- From:
Academic Journal of Second Military Medical University
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the antiamnesic effect of pregnenolone sialic glycoside on memory impairment in mice. Methods: Pharmacological model of amnesia in mice was produced by scopolamine. Learning and memory was evaluated using water maze performance of mice. Results: Significant memory deficit was induced by scopolamine (4 mg/kg, ip). Pregnenolone sulfate (0.1 5 mg/kg, sc ) failed to affect the scopolamine induced memory deficit. Pregnenolone sialic glycoside (0.1 5 mg/kg, sc) attenuated the deficit, decreased the time of finding platform, the errors of entering non exit and swimming distance at a dose of 1 mg/kg ( P
