Effects of TFC on the right ventricle papillary muscles of guinea pig
- VernacularTitle:广枣总黄酮对豚鼠右心室乳头肌的影响
- Author:
Shasha ZHANG
;
Yuhua WANG
;
Min AI
;
- Publication Type:Journal Article
- Keywords:
choeropondias axillaris;
total flavones of choeropondias axillaris(TFC);
guinea pig;
papillary muscle;
contractility;
functional refractory period (FRP);
excitability
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the mechanism of effects about total flavones of choeropondias axillaris(TFC) to heart. METHODS The effects of TFC on contractility were investigated through acting on the guinea pig right ventricle papillary muscles. RESULTS ① TFC decreased both the contractility and contraction rate of papillary muscles. ②The quantity effect curve of CaCl 2 was shifted to right after giving TFC. ③TFC 30.4 ?mol?L -1 prolonged remarkably the functional refractory period (FRP) of guinea pig right ventricle papillary muscles, but exerted no effect on excitability. CONCLUSION TFC can inhibit the Ca 2+ influx into cell in a concentration dependent manner.
