Protection of the ischemic and reperfused myocardium by sodium-hydrogen exchange inhibitor
- VernacularTitle:NHE1抑制剂对缺血及再灌流心肌的保护作用
- Author:
Changxun CHEN
;
Ruomin JIN
;
- Publication Type:Journal Article
- Keywords:
Na + H + exchange inhibitor;
heart;
ischemia;
reperfusion
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
During ischemia, the intracellular acidosis stimulates the Na +/H + exchanger. The increase in intracellular sodium secondary to increased Na +/H + exchange is reversed through exchange for calcium, resulting in calcium overload of the cells and producing cell injury and necrosis. NHE1 inhibitors exert a protective effect on myocardium subject to ischemia and reperfusion via reduction of Na +/H + exchange, attenuation of intracellular calcium accumulation and other mechanisms.
