Prelimenary studies on effects of resveratrol in inhibiting growth of HepG2 and inducing its apoptosis
- VernacularTitle:白藜芦醇抑制HepG2细胞生长及诱导细胞凋亡的初步研究
- Author:
Xuemei TIAN
;
Zhanxia ZHANG
;
- Publication Type:Journal Article
- Keywords:
resveratrol;
hepG2 cells;
cell apoptosis
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the effect of resveratrol on human liver cancer HepG2, and to study the function of resveratrol in inducing HepG2 apoptosis. METHODS HepG2 cells were treated with resveratrol at various concentrations. MTT assay was used to examine growth and proliferation of HepG2 cells after treatment with resveratrol for 24 hours. HE staining and electromicroscope were used to observe the morphology of apoptotic cells, and TUNEL, flow cytometry were also used to analyze the HepG2 apoptosis. RESULTS Resveratrol significantly inhibited growth and proliferation of HepG2 cells in dose dependent manner. And resveratrol also induced the apoptosis of HepG2 cells. CONCLUSION Resveratrol may inhibit HepG2 cell growth and proliferation through inducing apoptosis.
