Synthesis and antibacterial activity of 7-substituted-1-(2-fluoroethyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolone carboxylic acid compounds
- VernacularTitle:7-取代-1-(2-氟乙基)-6,8-二氟-1,4-二氢-4-氧-3-喹啉羧酸化合物的合成及其抗菌活性
- Author:
Bin YAO
;
Jingpu ZHAO
;
Bingxiang XU
;
- Publication Type:Journal Article
- Keywords:
fluoroquinolones;
chemical synthesis;
antibacterial activity,
- From:
Academic Journal of Second Military Medical University
2000;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the synthesis and antibacterial activity of 7 substituted 1 (2 fluoroethyl) 6,8 difluoro 1, 4 dihydro 4 oxo 3 quinolone carboxylic acid compounds. Methods: The title compounds were synthesized by condensation,cyclization, nucleophilic substitution. Antibacterial activity in vitro was determined with 6 kinds of common pathogenic bacteria. Results: Eleven compounds of 7 substituted 1 (2 fluoroethyl) 6,8 difluoro 1,4 dihydro 4 oxo 3 quinolone carboxylic acid were designed and synthesized. These compounds were firstly reported. The chemical structures of all compounds were determined by IR, 1HNMR and elementary analysis. CompoundⅠ 1,Ⅰ 2,Ⅱ 4 showed better antibacterial activities than that of fleroxacin. Conclusion: Some of the title compounds show potent antibacterial activities and should be further studied. [
