Antagonistic Effect of Grape Procvanidin or Linoic Acid to Rat laver Cell Peroxidative Damage Induced bv ~(60)Co ? Radiation
- VernacularTitle:葡多酚和硫辛酸对~(60)Co?射线致小鼠肝细胞自由基损伤的拮抗作用
- Author:
Bai-Yun ZHOU
;
Chuan-Long ZONG
;
- Publication Type:Journal Article
- Keywords:
Radiation;
Grape procyanidin;
Lipoic acid;
Lipid peroxidation;
Comet assay
- From:
Journal of Environment and Health
2007;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the antagonistic effects of grape procyanidin(GPC)or lipoic acid(LA)to the rat liver cell peroxidative damage induced by~(60)Co ? radiation.Methods The cultured rat liver cells(1?10~9/L)were prepared from 10 rats aged 1 week,the survival rate was above 85%.The cultured liver cells were divided into the negative control group(without radiation), GPC group(75 mg/L),LA group(100 mg/L)and the positive control group(containing no antioxidants),which were radiated by (60)~Co ? radiation(2.5 Gy,90 cm,10 s).The SOD,GSH-Px activity,MDA level and comet assay were determined.Results Compared with the positive control group,in the GPC group and LA group,the activity of hepatic SOD and GSH-Px were significantly higher (P
