Hypoglycemia associated with the abnormal expression of insulin like growth factor-Ⅱ in a pleural solitary fibroma
- VernacularTitle:胰岛素样生长因子Ⅱ表达异常与胸膜孤立性纤维瘤致低血糖
- Author:
Jieli LU
;
Yongju ZHAO
;
Ying WANG
;
Jingfen TANG
;
Weiqing WANG
;
Wei ZHANG
;
Jianming LIU
;
Bangyao LUO
;
Zhongyuan CHEN
;
Xiaolong JIN
;
Guang NING
;
Xiaoying LI
- Publication Type:Journal Article
- Keywords:
Insulin like growth factor-Ⅱ;
Solitary fibroma of pleura;
Non-islet cell tumor induced hypoglycemia
- From:
Chinese Journal of Endocrinology and Metabolism
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
High expressions of IGF Ⅱ mRNA and protein were demonstrated by RT PCR and IRMA analysis in tumor tissue of a patient with non islet cell tumor induced hypoglycaemia (NICTH). Northern blotting results displayed abundant 6.0, 5.3, 5.0, 4.8 kb IGF Ⅱ transcripts in the tumor. It suggests that autosecretive production of IGF Ⅱ of the tumor plays an important role in the pathogenesis of tumor induced hypoglycemia.
