Immunohistochemical Study about Expression of Caspase-3 in Hemangiomas
- VernacularTitle:Caspase-3在血管瘤组织中的表达及其意义
- Author:
Nan LI
;
Xinsheng CHEN
;
Daliang CHEN
;
- Publication Type:Journal Article
- Keywords:
Caspase-3 Hemangioma Apoptosis
- From:
Chinese Journal of Bases and Clinics in General Surgery
2003;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between expression of Caspase 3 and regression of hemangioma. Methods Caspase 3 expression was detected in 79 hemangiomas and 5 normal skin tissues by immunohistochemistry (SP). Results In 79 hemangiomas, the positive rates of Caspase 3 expression in proliferating, involuting and involuted phases were 52.4%, 91.2% and 83.3%, respectively. The expression of Caspase 3 in involuted and involuting phases was higher than proliferating phase( P 0.05). Conclusion Caspase 3 is involved in the converting of hemangiomas from proliferating phase into involuting phase. The activation of Caspase 3 may induce apoptosis of endothelial cells, thus leading to the regression of hemagioma.
