IL-6、IL-1? and TNF? induce the expression of c-fos and c -jun in human fetal cere-bral neurons
- VernacularTitle:IL-6、IL-1?、TNF?对人胎大脑神经细胞c-fos、c-jun的表达调控
- Author:
Zhiling PANG
;
Lanying LI
;
Jiao WEI
;
Xueqian YIN
;
- Publication Type:Journal Article
- Keywords:
Cytokine Cerebral Neuron c fos c
- From:
Chinese Journal of Immunology
1999;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effects of IL 6、IL 1? and TNF? on the expression of c fos and c jun,which may provide the foundation for a further study in clinic.Methods:Used the a model of primary culture of human fetal cerebral neurons in serum free medium,by DNA RNA dot blot hybrdization.Results:The expression of c fos and c jun was increased between 15 min to 30 min after stimulation,reached a maximum at 1 h and declined over the subsequent 1 h.Conclusion:IL 6、IL 1? and TNF ? have induce the expression of c fos and c jun during development of human fetal cerebral neurons in vitro at the level of transcription.
