The expression of adhesion molecule CD11a,CD11b,CD62L on malignant lymphoproliferative disorders and its clinical implications
- VernacularTitle:粘附分子CD11a、CD11b、CD62L在恶性淋巴增殖性疾病的表达
- Author:
Xiuzhen TONG
;
Shaokai LUO
;
Wende HONG
;
Al ET
- Publication Type:Journal Article
- Keywords:
Lymphosarocoma cell leukemia Acute leukemia lymophocytic Multiple myeloma Cell adhesion molecule
- From:
Chinese Journal of Immunology
2000;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression of adhesion molecule including CD11a、CD11b、CD62L on malignant lymophoproliferative disorders and its clinical implications.Methods:Adhesion molecule CD11a、CD11b、CD62L of 35 Acute Lymophocytic Leukemia(ALL)、30 multiple myeloma(MM)、4 Chronic Lymophocytic Leukemia(CLL)、14 lymphosarocoma cell leukemia patients and 25 health people were measured by flow cytometric analysis.Results:①CD11a and CD11b expression were lower on ALL、MM、CLL cells than the normal hematopoietic cells.CD62L expression were lower on CLL、MM、lymphosarocoma cell leukemic cells than the normal hematopoietic cells.②The CD11a was lower expressed on ALL than lymphosarocoma cell leukemic cells,CD62L was higher on ALL than lymphosarocoma cells leukemia.③The expression of CD11a in the ALL invasion group was much higher than that in the noninvasive group(P
