The development of a bioartificial liver and its application in acute liver failure patients
- VernacularTitle:生物人工肝构建及临床应用14例次报告
- Author:
Yitao DING
;
Qingxiang XU
;
Yudong QIU
;
Zhong CHEN
;
Qin TANG
;
Decai YU
;
Yijun YANG
;
Heyun ZHANG
- Publication Type:Journal Article
- Keywords:
Liver failure, acute;
Liver, artificial;
Membranes, artificial
- From:
Chinese Journal of General Surgery
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Using polysulfon fibers, a new bioartificial liver was developed. This study was to evaluate the efficacy of this bioartificial liver in the support of a disfunctioned liver. Methods Hepatocytes were procured from swine using Seglen′s methods. The bioartificial liver was constructed based on polysulfon bioreactor with a procurement of 10 10 hepatocytes, and was applied in 12 acute liver failure patients for 14 sessions. Each BAL treatment lasted 6 hours. The general conditions of the patients and the biochemical parameters were evaluated. Results After treatment with bioartificial liver, ammonia, prothrombin time and total bilirubin level significantly decreased (all P
