Cytokine genes expression of hepatic sinusoidal endothelial in mice with sepsis
- VernacularTitle:脓毒症小鼠肝窦内皮细胞细胞因子的基因表达
- Author:
Rongqian WU
;
Yingxin XU
;
Xuhua SONG
;
Xianjun MENG
;
- Publication Type:Journal Article
- Keywords:
WISSLER’S SYNDROME/gent;
?GENE EXPRESSION;
?TUMOR NECROSIS FACTOR;
?INTERLEUKIN 1;
?INTERLEUKIN 6;
?ENDOTHELINS
- From:
Chinese Journal of General Surgery
1993;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of cytokines genes expression of liver sinusoidal endothelial cells in liver damage by sepsis.Methods Septic mice models were established with cecal ligation and perforation (CLP), while sham operation group received the same procedure exclusive CLP. The genes expression of TNF?, IL 1? and IL 6 in liver sinusoidal endothelial cells were assessed by RT PCR. Results A significant increase of TNF?, IL 1? genes expression was observed at 3h, and a slight decline at 12h after operation, but still significantly higher than that in the sham group; while IL 6 gene expression showed signficantly higher at 3h and remained at the high level at 12h. Conclusions Liver sinusoidal endothelial cell is an important source of cytokine production in mice with sepsis.
