Effects of adrenaline on pharmacodynamics and pharmacokinetics of bupivacatine for interscalene plexus block
- VernacularTitle:肾上腺素对丁哌卡因肌间沟臂丛神经阻滞的药效学与药代动力学的影响
- Author:
Zhishuang LIU
;
Pengzhi GAO
;
Xiaoyan CHENG
;
Xin LI
;
Shuming WEI
;
Aixiang LIU
;
Shulan SONG
;
Qingyun MENG
- Publication Type:Journal Article
- Keywords:
Pharmacodynamics;
Pharmacokinetics;
Bupivacaine;
Adrenaline;
Brachial plexus;
Nerve block
- From:
Chinese Journal of Anesthesiology
1997;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effects of adrenaline on pharmacodynamics and pharmacokinetics of bupivacaine for interscalene plexus block. Method:Sixteen ASA gradeⅠ-Ⅱadult patients undergoing shoulder or upper limbs operation were randomly divided into two groups (n=8)). The plexus block was induced with 0.75％ bupivacaine 2 mg/kg or 0.75％ bupivacaine 2mg/kg plus 1:200 000 adrenaline. Clinical effects and plasma concentration,the Cmax and Tmax were compared between two groups. Result:The time to reach peak analgesia and the duration of analgesia were longer in adrenaline group than in control group(P
