Roles of inflammatory cytokines in acute graft-versus-host disease and their mechanisms
10.3760/cma.j.issn.0254-5101.2017.01.013
- VernacularTitle:炎症细胞因子在急性移植物抗宿主病中的作用及机制研究进展
- Author:
Shuangzhu LIU
;
Shoubao MA
;
Haiyan LIU
;
Depei WU
;
- Keywords:
aGVHD;
Proinflammator factor;
Suppressive factor;
Biomarkers;
Predictive value
- From:
Chinese Journal of Microbiology and Immunology
2017;37(1):78-82
- CountryChina
- Language:Chinese
-
Abstract:
Allogeneic hematopoietic stem cell transplantation ( allo-HSCT) is an effective therapy for the treatment of various malignant and non-malignant hematological diseases. Acute graft-verse-host-dis-ease ( aGVHD) , a major complication following allo-HSCT, is one of the predominant causes of GVHD-re-lated mortality. The development of aGVHD is a typical pathologic process with the release of inflammatory cytokines in great quantities, resulting in the occurrence ofcytokine storm and causing specific pathologi-cal damages by attacking the recipient organ. Therefore, identification of biomarkers specific for aGVHD of-fers promise to the treatment of aGVHD. In this review, we summarizes the functions of several typical in-flammatory cytokines, including IL-1β, IL-6, IL-17A and IL-10, and their mechanisms in the development of aGVHD in order to provide references for the prevention and treatment of aGVHD.
