Difference of Bcl-6 and c-myc gene translocation between Xinjiang Uygur and Han diffused large B-cell lymphoma subtypes
10.3969/j.issn.1000-8179.20141310
- VernacularTitle:新疆维汉弥漫大B细胞淋巴瘤中Bcl-6 c-myc基因易位的差异性研究
- Author:
Bing ZHAO
;
Xun LI
;
Wei LIU
;
Yan LI
;
Zhenhui ZHAO
;
Shune YANG
;
- Publication Type:Journal Article
- Keywords:
Bcl-6 gene;
c-myc gene;
diffuse large B-cell lymphoma
- From:
Chinese Journal of Clinical Oncology
2014;(19):1244-1248
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical significance of Bcl-6, c-myc gene abnormalities in Xinjiang Uygur and Han dif-fused large B-cell lymphoma (DLBCL) subtypes. Methods:Bcl-6, c-myc gene was detected by fluorescence in situ hybridization in 233 patients with DLBCL . A relationship was observed among Bcl-6, c-myc gene translocation, and clinical data in DLBCL patients. In addition, a difference was observed among Bcl-6, c-myc gene translocation, and different ethnic groups in different subtypes of DLB-CL. Results:Among the 233 patients, 51 cases (21.89%) had rearranged Bcl 6 gene, and 39 cases (16.74%) had rearranged c-myc gene. Bcl-6 gene translocation and expression was related with age, gender, disease location, clinical stage, and LDH levels (P>0.05), but was not related with nationality , international prognostic index score, extranodal involvement, B symptoms, DLBCL subtypes, and recent efficacy (P<0.05);c-myc gene translocation and expression was related with age, gender, disease location, clinical stage LDH levels, and DLBCL subtypes (P>0.05), but was not related with nationality, IPI score, extranodal involvement, B symptoms, and recent effica-cy (P<0.05). In the Uygur and Han GCB groups, Bcl-6, c-myc gene translocation showed no significant difference (P>0.05). By con-trast, in the Uygur and Han non-GCB groups, Bcl-6, c-myc gene translocation showed significant difference (P>0.05). Conclusion:Bcl-6, C-myc gene translocation was related with age, gender, disease location, clinical stage, and LDH levels. Bcl-6 gene translocation was also correlated with different subtypes of DLBCL.
