Association between Antipsychotic-Related Restless Legs Syndrome and the RORA Gene Polymorphism in Schizophrenia.
10.16946/kjsr.2013.16.2.93
- Author:
Jin Sook JUNG
;
Chul Hyun CHO
;
Ho Kyoung YOON
;
Seung Gul KANG
;
Young Min PARK
;
Heon Jeong LEE
;
Leen KIM
- Publication Type:Original Article
- Keywords:
RLS;
Schizophrenia;
RORA;
Genetic polymorphism;
Circadian rhythm
- MeSH:
Child;
Child, Orphaned;
Circadian Rhythm;
Gene Frequency;
Genetic Predisposition to Disease;
Genotype;
Humans;
Polymerase Chain Reaction;
Polymorphism, Genetic;
Restless Legs Syndrome*;
Schizophrenia*
- From:Korean Journal of Schizophrenia Research
2013;16(2):93-97
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: The previous studies have suggested genetic vulnerability to restless legs syndrome (RLS) development. The occurrence of antipsychotic-related RLS could also be attributable to differences in genetic susceptibility. This study aimed to investigate whether Retinoid-related orphan receptor A (RORA) gene polymorphism is associated with antipsychotic-related RLS in schizophrenia. METHODS: We assessed symptoms of antipsychotic-induced RLS in 190 Korean schizophrenic patients and divided the subjects into two groups according to the International Restless Legs Syndrome Study Group diagnostic criteria : 1) subjects that met all of the criteria (n=44) and 2) the remaining subjects who were not considered to be RLS patients (n=146). Single-nucleotide polymorphism in the RORA gene was genotyped by PCR in 190 individuals. The chi2-test was conducted to compare differences between two groups. RESULTS: The frequencies of genotype (chi2=0.066, p=0.968) of the RORA gene (rs11071547) did not differ significantly between schizophrenic patients with and without RLS. The difference of allele frequencies (chi2=0.008, p=0.927) of the RORA gene (rs 11071547) between the schizophrenic patients with and without RLS were not significant. CONCLUSION: These results suggest that RORA gene polymorphism does not play a major role in susceptibility to antipsychotic-related RLS in schizophrenia.
