Clinical outcome of adjuvant chemotherapy plus intensity modulated radiotherapy after breust-con-serving surgery
10.3760/cnm.j.issn.1004-4221.2009.06.463
- VernacularTitle:乳腺癌保乳术后化疗加调强放疗的疗效观察
- Author:
Munire Musajiang
;
Simayili Maimaitiniyazi
;
Fang CHENG
;
Xiu-qing AI
;
Chun-yu HE
;
Xiang-lu ZHU
;
Mukedaisi Baiketiyaer
;
Su-ling XU
;
Hao LIU
;
Guo-qing ZHANG
;
Abudushalamu
- Publication Type:Journal Article
- Keywords:
Breast neoplasms/chemotherapy;
Breast neoplasms/radiotherapy;
Radiotherapy,intensity modulated;
Prognosis
- From:
Chinese Journal of Radiation Oncology
2009;18(6):463-465
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and side effects of adjuvant chemotherapy plus in-tensity modulated radiotherapy (IMRT) after breast-conserving surgery for stage Ⅰ and Ⅱ breast cancer.Methods After breast-conserving surgery, 108 patients received six cycles of chemotherapy followed by IM-RT. The irradiation dose of the whole breast was 50 Gy given by 25 fractions, followed by 10 Gy boost to the tumor bed given by 5 fractions with electron beams. Patients with positive estrone receptor or progesterone re-ceptor were given endocrine treatment, mostly with tamoxifen. Results The follow-up rate was 100% by December 2007. The number of patients followed-up at 1-, 2- and 3-year was 108,88 and 58. The 1-, 2- and 3-year over survival rates were 100% ,100% and 98%. Three patients had local recurrence. Different degree of dermatitis occurred with good long-term cosmetic results. No severe side effects occurred such as radiation-induced pneumonitis, pulmonary fibrosis and heart injury. Conclusions Breast cancer patients treated by adjuvant chemotherapy plus IMRT after breast-conserving surgery have high survival rate and low side-effect rate. The survival quality and local control can be improved.
