Multidrug resistant gene mdr1 expression in oral squamous cell carcinoma before and after chemotherapy
- VernacularTitle:口腔鳞癌化疗前后多药耐药基因表达变化的分析研究
- Author:
Jie ZHANG
;
Jianguo ZHANG
;
Fuyun ZHAO
- Publication Type:Journal Article
- Keywords:
Squamous cell carcinoma;
Multidrug resistant gene;
Drug therapy
- From:
Journal of Practical Stomatology
2000;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To compare the expression of multidrug resistant gene( mdr 1 ) in oral squamous cell carcinoma (SCC) before and after chemotherapy. Methods: Mdr 1 gene expression in 21 cases of oral SCC was detected before and after chemotherapy by dot blot hybridization, Results: Before and after sigle drug chemotherapy mdr1 mRNA(?10 5 copies/?g) in SCC tissue was 1.98?1.72 and 3.74?3.24( P
