Association between disease activity and osteocalcin, β-isomerized C-terminal telopeptides in SAPHO syndrome
10.3760/cma.j.issn.1007-7480.2016.05.004
- VernacularTitle:SAPHO综合征临床活动性与骨钙素和β异构C末端肽的相关性分析
- Author:
Chen LI
;
Shuo ZHANG
;
Jinhe LIU
;
Zhenhua DONG
;
Wen ZHANG
- Publication Type:Journal Article
- Keywords:
Osteocalcin;
Synovitis,acne,pustulosis,hyperostosis and osteitis syndrome;
β-isomerized C-terminal telopeptides
- From:
Chinese Journal of Rheumatology
2016;20(5):304-307
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between disease activity and osteocalcin,β-isomerized C-terminal telopeptides (β-CTX) in SAPHO syndrome.Methods We studied 58 cases who were diagnosed as SAPHO syndrome.The following indices used to assess the activity of SAPHO were measured:Bath ankylosing spondylitis Disease activity index (BASDAI),Bath ankylosing spondylitis functional index(BASFI),visual analogue scale (VAS) pain and erythrocyte sedimentation rate (ESR),C-reactive protein (CRP),osteocalcin and β-CTX.The SAPHO patients were divided from two groups according to the disease activity.The relationships were analyzed with t-test and Pearson's test.Results The β-CTX of the active group(0.43±0.20) ng/ml was elevated than the stable group (0.23 ±0.09) ng/mL (t=-4.620,P=0.007).And there was no significant difference in the osteocalcin between the active group (2.7±1.0) μg/L and the stable group(2.4±1.0) μg/L (t=-1.169,P=0.820).There was no significant correlation between the serum osteocalcin and ESR or hypersensitive CRP (hs-CRP) (rESR=0.228,PESR=0.088;rhsCRP=-0.085,PhsCRP=0.528).And β-CTX level was related to the VAS (r=0.496,P＜0.01),BASDAI (r=0.401,P=0.002) and BASFI (r=0.295,P=0.025).While no significant relationship between the osteocalcin and pain index was observed in our study.Conclusion The positive correlation between serum β-CTX and disease activity indicates significant bone absorption during the bone destroy process in SAPHO syndrome.
