Determination of Sodion and Salt-forming Rate in Cefalotin Sodium by Ion Chromatography
- VernacularTitle:离子色谱法测定头孢噻吩钠中钠离子含量以及成盐率考察
- Author:
Hongliang WEN
;
Jingdan ZHAO
;
Feng QIN
;
Ya QIU
;
Hao LIU
;
Meicheng YANG
- Publication Type:Journal Article
- Keywords:
Ion chromatography;
Cefalotin sodium;
Sodion;
Salt-forming rate
- From:
China Pharmacist
2015;(2):212-215
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish a method for the determination of sodion in cefalotin sodium by ion chromatography and investi-gate the salt-forming rate of the products. Methods: A TSKgelSuper IC-CR cation exchange column (150 mm × 4. 6 mm, 3. 0 μm) was used. The mobile phase was the mixture of 2. 2 mmol·L-1 methanesulfonic acid and 1 mmol·L-1 18-crown-6-ether with the flow rate of 0. 8 ml·min-1 . The column temperature was 40℃ and the injection volume was 20μl. The detector was an electric conductiv-ity detector. Results:The linear correlation of sodion was good within the range of 3. 0-60. 0μg·ml-1(r=0. 999 9). The average re-covery was 99. 8%(RSD=0. 8%, n=9). The mole number ratio of sodion to cefalotin was within the range of 0. 97-1. 03. Conclu-sion:The method is specific, precise and accurate, and can be used in the determination of sodion in cefalotin sodium. The salt-form-ing rate of the 8 batches of samples is promising.
