Effect of dexmedetomidine on proliferation, migration and invasion of human gastric cancer SGC-7901 cells
- VernacularTitle:右美托咪定对胃腺癌SGC-7901细胞生长和转移的影响
- Author:
Jianhua TONG
1
;
Ningning JI
;
Manlin DUAN
;
Zhiqiang ZHOU
;
Ming XIA
;
Jianguo XU
Author Information
1. 东南大学附属中大医院麻醉科
- Keywords:
Dexmedetomidine;
Gastric cancer;
Proliferation;
Migration;
Invasion
- From:
The Journal of Clinical Anesthesiology
2017;33(11):1096-1098
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe different behavior of proliferation,migration and invasion of SGC-7901 cells when exposured to dexrnedetomidine of different concentrations.Methods Human gastric cancer cells SGC-7901 were inoculated on culture plate for 24 h,then were randomly divided into 5 groups:control group (group C),dexmedetomidine 312.5μg/ml group (group D1),dexme detomidine 625μg/ml group (group D2),dexmedetomidine 1 250 μg/ml group (group D3),dexmedetomidine 2 500 μg/ml group (group D4).Each group was medicated and incubated for 48 h,then the cell proliferation,migration and invasion immediately were detected by CCK-8 and Transwell.Results SGC-7901 cell viability of groups D1,D2,D3 和 D4 had no significant difference compared with that of group C.The invasion ability and migration ability of SGC-7901 cells in groups D1,D2,D3 and D4 were significantly higher than those in group C (P ＜ 0.05 or P ＜ 0.01).Conclusion Dexmedetomidine can promote migration and invasion of SGC-7901 cells.
