Iodine-rich diet and thyroid cancer: a Meta-analysis
10.3760/cma.j.issn.2095-4255.2017.11.014
- VernacularTitle:富含碘的饮食与甲状腺癌关系的Meta分析
- Author:
Yi PANG
1
;
Zheng LU
;
Peng JIANG
;
Yunfeng GUAN
;
Xing JIN
;
Hongmei SHEN
Author Information
1. 哈尔滨医科大学中国疾病预防控制中心地方病控制中心碘缺乏病防治研究所国家卫生计生委病因流行病学重点实验室黑龙江省普通高校病因流行病学重点实验室
- Keywords:
Thyroid neoplasms;
Risk factors;
Case-control study;
Meta-analysis
- From:
Chinese Journal of Endemiology
2017;36(11):840-845
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between iodine-rich diet and thyroid cancer.Methods PubMed,Excerpt Medica Database (EMbase),China National Knowledge Infrastructure (CNKI),WanFang,WeiPu,and China Biology Medicine disc (CBM) were searched through computer,for relevant articles published before June 2016,to find case-control studies concerning the relationship between iodine-rich diet and thyroid cancer.According to the inclusion and exclusion criteria for data extraction and quality evaluation,Meta-analysis was performed using Stata 12.0.Results Totally 19 case-control studies were included in this study.Cases and controls were 47 316 people (case 6 662,control 40 654).The quality of the literature was reliable (the score was 6 points and more).Meta analysis results showed a total of 13 articles studied fish,more frequent intake (3 times per week and more) of fish can reduce the risk of thyroid cancer [odds ratio (OR) =0.87,95％ confidence interval (CI):0.77-0.98,P ＜ 0.05];except saltwater fish,a total of 16 articles studied seafood,more frequent intake of seafood (3 times per week and more) increases the risk of thyroid cancer (OR =1.48,95％CI:1.11-1.99,P＜ 0.05).Study factors subgroup analysis showed that seafood (OR =2.23,95％CI:1.45-3.45,P ＜ 0.05),marine animal food (OR =9.48,95％CI:5.03-17.88,P ＜ 0.05) and seaweed (OR =1.93,95％CI:1.39-2.69,P ＜ 0.05) can increase the risk of thyroid cancer,shellfish (OR =1.21,95％CI:0.94-1.56,P ＞ 0.05),saltwater fish (OR =0.94,95％CI:0.50-1.77,P ＞ 0.05)and freshwater fish (OR =0.90,95％CI:0.66-1.21,P ＞ 0.05) had no effect on the prevalence of thyroid cancer.Conclusion Seafood,marine animal foods and seaweed will increase the risk of thyroid cancer.
