The correlation between level of serum APPL1 and urinary albumin excretion rate in patients with type 2 diabetes mellitus
10.3760/cma.j.issn.1000-6699.2017.10.005
- VernacularTitle:2型糖尿病患者血清APPL1与尿白蛋白排泄率的相关性研究
- Author:
Shuang LIU
1
;
Ying SHAO
;
Can WU
;
Huiwen REN
;
Min YANG
;
Li AN
;
Jing YU
;
Qiuyue WANG
Author Information
1. 中国医科大学附属第一医院内分泌科
- Keywords:
Diabetes mellitus;
type 2;
Adaptor protein;
phosphotyrosine interacting with PH domain and leucine zipper 1;
Diabetic kidney disease;
Urinary albumin excretion ratio
- From:
Chinese Journal of Endocrinology and Metabolism
2017;33(10):833-837
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of adaptor protein,phosphotyrosine interacting with PH domain and leucine zipper 1(APPL1)with urinary albumin excretion rate in patients with type 2 diabetes mellitus (T2DM),and to explore the role of APPL1 in the development of diabetic kidney disease(DKD). Methods According to the urinary albumin/creatinine ratio(UACR),288 newly-diagnozed patients with T2DM were divided into normal albuminuria group(UACR<30 mg/g,n=116),microalbuminuria group(UACR 30 ~300 mg/g,n=95),and macroalbuminuria group(UACR>300 mg/g,n=77). 130 healthy subjects with matched sex and age were used as control group. Serum APPL1,tumor necrosis factor α(TNF-α),and adiponectin levels were measured by ELISA method. Results Serum APPL1 level in T2DM patients was significantly higher than that in control subjects (P<0.01), and increased with the rising of UACR. In patients with T2DM, serum APPL1 level was negatively correlated with estimated glomerular filtration rate(r=-0.246, P<0.01) while it was positively correlated with HbA1C, low density lipoprotein cholesterol, total cholesterol, triglycerides, insulin resistance index, serum creatinine,blood urea nitrogen, systolic blood pressure, TNF-α, and adiponectin(r=0. 119, 0. 167, 0. 209, 0.194,0.273,0.242,0.131,0.144,0.365, and 0.952, respectively, P<0.05 or P<0.01). Conclusion Serum APPL1 level in patients with T2DM was increased with the rising of UACR, suggesting that APPL1 may be involved in the development of DKD.
