6-sulfo LacNAc dendritic cells and tumors
10.3760/cma.j.issn.1673-422X.2017.11.007
- VernacularTitle:6-磺基N-乙酰乳糖胺树突状细胞与肿瘤
- Author:
Denglin CHEN
1
;
Junmin CHEN
Author Information
1. 海南省人民医院肿瘤内科
- Keywords:
Dendritic cells;
Neoplasms;
Immunity
- From:
Journal of International Oncology
2017;44(11):834-837
- CountryChina
- Language:Chinese
-
Abstract:
6-sulfo LacNAc dendritic cells (slanDCs),characterized by expressing the Fc receptors that absent in classic dendritic cells (DCs),have been identified as a novel subgroup of peripheral blood DCs.Hitherto,the majority researches of slanDCs are about inflammation and autoimmunity diseases,but a growing body of literature has shown that slanDCs may play important roles in anti-tumor immunity by inducing antibody-dependent cell-mediated cytotoxicity,releasing special cytokines,cross-talking with mesenchymal stem cells or natural killer cells,and signal transduction through Toll-like receptor pathway and mitogen-activated protein kinase pathway.slanDCs may be an ideal anti-tumor therapy tool.
