Diagnostic value of neck ultrasonography and 18F-FDG PET/CT imaging during the follow-up of differentiated thyroid carcinoma patients with elevated serum TgAh
10.3760/cma.j.issn.2095-2848.2017.12.005
- VernacularTitle:颈部超声和18F-FDG PET/CT显像在血清TgAb阳性DTC患者随访中的诊断价值
- Author:
Jiao LIU
1
;
Baoping LIU
;
Biao DU
;
Bing CHENG
;
Xingmin HAN
;
Yan LIU
;
Zhihua YAN
;
Tingting LIU
Author Information
1. 450052,郑州大学第一附属医院核医学科
- Keywords:
Thyroid neoplasms;
Thyroglobulin;
Antibodies;
Ultrasonography;
Positron-emission tomography;
Tomography,X-ray computed;
Deoxyglucose
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2017;37(12):772-776
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic value of neck ultrasonography (NUS) and 18F-FDG PET/CT imaging during the follow-up of DTC patients with elevated serum TgAb but negative serum Tg and 131I-Dx-WBS after thyroidectomy and 131I ablation.Methods From September 2014 to March 2016,41 DTC patients (10 males,31 females,age 16-73 years) with elevated serum TgAb level (＞115 kU/L) but negative serum Tg and 131I-Dx-WBS were enrolled in this prospective study.Patients were divided into positive group and negative group,according to the results of NUS.The rates of recurrence or metastasis between the 2 groups were compared.18F-FDG PET/CT imaging was performed and the results were compared with pathological results.x2 test was used to analyze the data.Results The rate of recurrence or metastasis in the NUS positive patients(9/17) was significantly higher than that in the patients with negative NUS results (16.67％,4/24;x2 =6.047,P＜0.05).The sensitivity,specificity,positive predictive value,negative predictive value of 18F-FDG PET/CT imaging for diagnosis of recurrence or metastasis were 12/13,78.57％ (22/28),12/18 and 95.65％ (22/23) respectively.ROC curve analysis showed that the sensitivity and specificity of 18F-FDG PET/CT imaging were 11/13 and 100％ (28/28) respectively when the threshold of SUVmax was set at 4.35.The treatment strategy was changed after 18 F-FDG PET/CT imaging in 12 patients,of which 8 underwent surgery and 4 underwent 131I ablation therapy.Conclusion The NUS and 18F-FDG PET/CT imaging have important significance in clinical diagnosis and subsequent treatment of the DTC patients with elevated serum level of TgAb but negative serum Tg and 131I-Dx-WBS.
