Metabolic disorder and polycystic ovary syndrome: Challenges and opportunities

VernacularTitle:代谢紊乱与多囊卵巢综合征:挑战与机遇
Author: Wei LIU ¹ ; Shengxian LI
Author Information

1. 200127,上海交通大学医学院附属仁济医院内分泌代谢科
Keywords: Polycystic ovary syndrome; Metabolic disorder; Proteomics; Lipidomics/metabolomics
From: Chinese Journal of Endocrinology and Metabolism 2017;33(12):1007-1011
CountryChina
Language:Chinese
Abstract: Polycystic ovary syndrome ( PCOS) is a complex syndrome with clinical manifestations of both endocrine and metabolic disorders. The etiology and pathogenesis are complex. PCOS seriously affects reproductive function, and also significantly increases the risk of metabolic and cardiovascular diseases, which often requires long-term intervention, with uncertain efficacy. Proteomics and lipidomics/metabolomics are efficient methods to determine the metabolic disorders using liquid/gas chromatography-tandem mass spectrometry ( LC/GC-MS/MS ) . A deeper understanding of the metabolic characteristics presented in different subtypes of PCOS may, in future, be able to find new biomarkers and to guide some novel precise interventions.