Progress in arsenic carcinogenesis
10.3760/cma.j.issn.2095-4255.2017.12.019
- VernacularTitle:砷致癌机制研究进展
- Author:
Qing ZHOU
1
;
Wei CHEN
;
Shuhua XI
Author Information
1. 中国医科大学公共卫生学院地球化学性疾病研究室
- Keywords:
Arsenic;
Cancer,Genotoxicity;
Epigenetic changes
- From:
Chinese Journal of Endemiology
2017;36(12):933-936
- CountryChina
- Language:Chinese
-
Abstract:
Arsenic is one of the chemical pollutants,which is widely distributed in natural environment.International agency for research on cancer (IARC) has made it clear that arsenic and its compounds are carcinogens;endemic arseniasis has become a public health problem that seriously endangers human health.However,the arsenic metabolic and toxic effects of the species vary widely,failure to replicate a suitable carcinogenic model on animals,and there is no recognized carcinogenic mechanism.The author provide a brief review of arsenic metabolism,arsenic genotoxicity,arsenic-induced epigenetic changes,arsenic-induced changes in cell signaling pathways,arsenic and estrogen receptor expression,and arsenic immunotoxicity,to provide a reference for control and prevention of endemic arseniasis.
